Monday, October 19, 2020

Participating in a Covid-19 vaccine trial

 I am participating in a Covid-19 vaccine trial. It's for the Novavax vaccine. My first inoculation was in the early fall. After the Day 0 inoculation I developed a low-grade fever as shown in the photo, so I am assuming that I was not in the placebo group. My Day 21 vaccine did not cause any fever or other symptoms. I go back for my last vaccination in February 2021. The Novavax vaccine is not a mRNA vaccine like the Pfizer and Moderna vaccines. Instead, the Novavax vaccine is a Covid-19 spike protein. The gene sequence of a Covid-19 spike protein is cloned into baculoviruses, which are then inoculated into moth cells, which in turn produce the protein. The spike proteins are then engineered to form micelles, agglomerations of the spike protein close in size to the virus. This recombinant vaccine is far more engineered than those they are use attenuated viruses, but it doesn't rely on the host's cellular machinery to make the vaccine like mRNA vaccines. 


Sunday, October 18, 2020

Documenting my participation in a Covid-19 vaccine trial

There weren't many requirements for participating in the trial. I had to administer Covid tests to myself several times and mail in my swabs. I also had to donate blood at intervals after each vaccination.  After a dose, I had to complete a series of questions through an app in my phone. The questions were about any symptoms I might have experienced immediately after my shot. I was struck by the ordinariness of the vaccine trial. It was like going to the doctor for a regular checkup. I did not belabor the decision, although I periodically reflect upon the likelihood of any immune enhancement effects. This is when exposure to a vaccine inadvertently triggers a heightened response to the pathogen when exposure does occur. Will I get take another vaccine when they become available to the public? I'll have to wait and see what the numbers come out to be all the vaccines. Look for a combined flu/Covid vaccine for the 2022-2023 viral respiratory season.